When to do a prostate biopsy for an elevated PSA-Well….that depends.


The PSA is very dependable after treatment for prostate cancer but not as much so before the diagnosis.

Prostate Diaries

  • A lot of what folks do depends on “who they are.”  The anxious patient may want to pursue a biopsy the first time it is elevated. The idea of waiting a couple a weeks and maybe a course of “empiric” antibiotics is something they don’t want to do. Another “calmer” type patient might wait months or as I have seen,”I’ll just repeat it at my yearly Doc.”
  • It is always reasonable to repeat any lab value that is elevated. With the PSA, a two-week interval with or without antibiotics is something I commonly recommend.
  • If there is a history of prostate cancer in the family that would make one more inclined to do a biopsy.
  • The rectal exam trumps the PSA…so i the PSA is high and you are questioning the results and you want to repeat it…to most urologists, if the PSA is normal and the rectal exam has…

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