Yes you can have prostate cancer with normal PSA .
- When tumors are described by way of its differentiation, i.e. well differentiated, poorly differentiated, what they are talking about is how close or how far away is from a normal one.
- In prostate cancer the Gleason’s score is a way to describe how a cell is differentiated.
- A Gleason 6 is a well-moderately differentiated cancer.
- A Gleason 8 or above is a poorly differentiated cancer.
- A well differentiated prostate cancer is harder to call for the pathologist than a moderately differentiated cancer because the well differentiated cell more closely resembles the normal prostate cell.
- A poorly differentiated prostate cancer cell is an easy to call for the pathologist because its architecture is so far removed from how a normal cell looks…it is sometimes described as “bizarre.”
- A poorly differentiated cell however can be tricky for the pathologist because it can be so bizarre looking that…
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